Detection of Colorectal Neoplasm Using Promoter Methylation of Stool Dna in Stool Samples in Korean Patients
نویسندگان
چکیده
منابع مشابه
Detection of the ITGA4, SFRP2 and p16 Promoter methylation in stool for colorectal neoplasm detection in Korean patients- A preliminary report
Purpose: Colorectal cancer (CRC) screening method using stool DNA testing has shown greater detection rate than conventional fecal occult blood testing. The aim of this study was to determine the sensitivity and specificity of detection method using three promoter methylation markers of the ITGA4, SFRP2 and p16 for colorectal adenoma and carcinoma. Methods: The methylation status of the ITGA4, ...
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We have used a gene expression array-based strategy to identify the methylation of tissue factor pathway inhibitor 2 (TFPI2), a potential tumor suppressor gene, as a frequent event in human colorectal cancers (CRC). TFPI2 belongs to the recently described group of embryonic cell Polycomb group (PcG)-marked genes that may be predisposed to aberrant DNA methylation in early stages of colorectal c...
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BACKGROUND Analysis of aberrant hypermethylation in stool DNA might provide a novel strategy for noninvasive detection of colorectal cancer. AIMS To explore the feasibility of detecting hypermethylation in Spastic paraplegia-20 promoter as a stool-based DNA marker for detection of colorectal cancer. METHODS We collected 96 tissue and stool samples from patients with colorectal cancer and 30...
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متن کاملStool DNA and colorectal-cancer screening.
Colorectal-cancer screening in the United States is a success story. The American Cancer Society recently reported that rates of death from colorectal cancer are down by 46% from their peak.1 There is good evidence that screening efforts have played an important role in the trend.2 However, work remains to be done, since approximately one third of Americans report not being current with screeni...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2014
ISSN: 0923-7534
DOI: 10.1093/annonc/mdu333.64